Abstract
Luteolin is a natural flavonoid found in a variety of vegetables and medicinal plants. It has a variety of pharmacological effects, including anti-tumor, anti-oxidation, anti-inflammatory, protective nervous system, etc. It is a widely-existing and compounds of medicinal value. With the deepening of the research on Luteolin, the molecular mechanism of its pharmacological effects has been recognized. In recent years, the research progress of the pharmacological effects of Luteolin has been reviewed, and the molecular mechanism is introduced.
Summary of Luteolin
Luteolin is a natural tetrahydroxy-flavone compound (Fig.1), widely found in vegetables and fruits, such as celery, broccoli, chrysanthemum, carrot, pepper, cabbage, apple peel and onion leaves. Luteolin is often present in the form of glycosylation, in celery、 green pepper、 Perilla and chamomile. Luteolin has a variety of pharmacological activities, and plants rich in luteolin are often used as traditional Chinese medicine to treat diseases. With the deep research on luteolin, it has been found to have anti-tumor effects such as inhibiting tumor cell proliferation, inducing tumor cell apoptosis and sensitizing anticancer drug activity, and also has anti-inflammatory, anti-oxidation and protection to the nervous system effect.
Luteolin can express an increase in the matrix metalloproteinase -9(matrix metalloproteinase-9) and metallothionein (metallothionein, MT) I / II in the liver, remove fibrin deposits, and repair liver fibrosis induced by CCl4. Pretreatment with luteolin can attenuate liver oxidative stress induced by CCl4, increase the activity of Cu/Zn SOD, and decrease aspartate aminotransferase (AST) in serum and alanine aminotransferase (ALT)activity, slowing the occurrence of liver fibrosis. Luteolin can reduce the production of ROS and hydroxyl radicals in the rat aorta with high glucose damage, increase the activity of SOD, and significantly increase the content of NO and the activity of nitric oxide synthase (NOS).
These results show that Luteolin can reduce high glucose-mediated endothelium-dependent vasodilatation damage by reducing oxidative stress and enhancing NOS-NO pathway. Kim et al found that treatment of rat bone marrow mononuclear cells with NF-κB receptor activator for nuclear factor κB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) Inducing cells to differentiate into osteoclasts. When luteolin is administered simultaneously, the activity of tartrate-resistant acid phosphatase (TRAP), The iconic enzyme of osteoclasts -the activity of tartrate-resistant acid phosphatase (TRAP) is significantly reduced, and cells containing the enzyme are significantly reduced. At the same time, luteolin also significantly reduced the bone resorption capacity of osteoclasts. Luteolin not only reduces osteoclast differentiation but also affects its function, which is of great help in the treatment of osteoporosis caused by oophorectomy.
The next chapter, we will introduce his function, please continue to pay attention...
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